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This article explored career compromise as negotiated by working-class adults pursuing science-related careers. Using a multiple case study method, we focused on eight individuals who participated in an interview about their career choices and then were followed longitudinally for two years. All participants were first-generation college students from working-class families and, at the start of the study, were enrolled at a community college. The results highlight key factors that influenced initial compromises including time and financial constraints, family obligations, and lacking requisite skills. In addition, renegotiations of initial career compromises were sparked by plateaus at work, role models, wanting more money, and having limited time. An extended window of time and financial resources were critical for sustained college pursuit two years later. Implications for career development initiatives are discussed.